Pulse the Oreos (filling and all) in a food processor until fine crumbs form.
Add the cream cheese and pumpkin pie spice to the crumbs and pulse until a thick dough forms.
Roll the dough into 1-inch balls and place on a parchment-lined baking sheet. Freeze 20 minutes until firm.
Melt the orange candy melts in the microwave in 30-second bursts, stirring between each, until smooth.
Dip each truffle in the melted candy, letting excess drip off, and return to the parchment. Drizzle with any remaining melted coating for a web look. Chill 10 minutes to set.